Ferrets as a Transmission Model for Influenza: Sequence Changes in HA1 of Type A (H3N2) Virus
Identifieur interne : 001839 ( Main/Exploration ); précédent : 001838; suivant : 001840Ferrets as a Transmission Model for Influenza: Sequence Changes in HA1 of Type A (H3N2) Virus
Auteurs : M. Louise Herlocher [États-Unis] ; Stephanie Elias ; Rachel Truscon ; Sean Harrison ; David Mindell ; Carl Simon ; Arnold S. MontoSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2001.
Abstract
Ferrets were used as an animal model to study whether controlled transmission of type A influenza is similar to human transmission when sequence changes in HA1 are used as the outcome. Ferrets were infected initially with A/Sydney/5/97 (H3N2) or A/LA/1/87 (H3N2) intranasally, and transmission chains were established by housing infected ferrets with noninfected ferrets with no influenza antibody titer against the infecting virus. Ferrets infected with A/Sydney were seronegative for A/Sydney and A/LA; ferrets infected with A/LA were seronegative for A/LA but had hemagglutination inhibition titers against A/Sydney. Titers of naturally transmitted influenza were higher than those after direct intranasal infection, but lymphocyte counts from nasal washes diminished with transmission. Ferrets infected with A/LA had 2 amino acid differences in HA1 after transmission through 5 ferret cohorts, but those infected with A/Sydney had none. The results show the value of the ferret model. A/LA resembled the transmission of influenza in humans when under antibody pressure
Url:
DOI: 10.1086/322801
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001513
- to stream Istex, to step Curation: 001513
- to stream Istex, to step Checkpoint: 000666
- to stream Main, to step Merge: 001879
- to stream Main, to step Curation: 001839
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Ferrets as a Transmission Model for Influenza: Sequence Changes in HA1 of Type A (H3N2) Virus</title><author><name sortKey="Herlocher, M Louise" sort="Herlocher, M Louise" uniqKey="Herlocher M" first="M. Louise" last="Herlocher">M. Louise Herlocher</name></author><author><name sortKey="Elias, Stephanie" sort="Elias, Stephanie" uniqKey="Elias S" first="Stephanie" last="Elias">Stephanie Elias</name></author><author><name sortKey="Truscon, Rachel" sort="Truscon, Rachel" uniqKey="Truscon R" first="Rachel" last="Truscon">Rachel Truscon</name></author><author><name sortKey="Harrison, Sean" sort="Harrison, Sean" uniqKey="Harrison S" first="Sean" last="Harrison">Sean Harrison</name></author><author><name sortKey="Mindell, David" sort="Mindell, David" uniqKey="Mindell D" first="David" last="Mindell">David Mindell</name></author><author><name sortKey="Simon, Carl" sort="Simon, Carl" uniqKey="Simon C" first="Carl" last="Simon">Carl Simon</name></author><author><name sortKey="Monto, Arnold S" sort="Monto, Arnold S" uniqKey="Monto A" first="Arnold S." last="Monto">Arnold S. Monto</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B272032214F4DC7471507AF029E0C0D3C613D27F</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1086/322801</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-H8VWR4NG-S/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001513</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001513</idno><idno type="wicri:Area/Istex/Curation">001513</idno><idno type="wicri:Area/Istex/Checkpoint">000666</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000666</idno><idno type="wicri:doubleKey">0022-1899:2001:Herlocher M:ferrets:as:a</idno><idno type="wicri:Area/Main/Merge">001879</idno><idno type="wicri:Area/Main/Curation">001839</idno><idno type="wicri:Area/Main/Exploration">001839</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Ferrets as a Transmission Model for Influenza: Sequence Changes in <hi rend="italic">HA1</hi> of Type A (H3N2) Virus</title><author><name sortKey="Herlocher, M Louise" sort="Herlocher, M Louise" uniqKey="Herlocher M" first="M. Louise" last="Herlocher">M. Louise Herlocher</name><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Reprints or correspondence: Dr. M. Louise Herlocher, Dept. of Epidemiology, School of Public Health, University of Michigan, 109 Observatory St., Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Elias, Stephanie" sort="Elias, Stephanie" uniqKey="Elias S" first="Stephanie" last="Elias">Stephanie Elias</name><affiliation><wicri:noCountry code="no comma">Epidemiology and</wicri:noCountry></affiliation></author><author><name sortKey="Truscon, Rachel" sort="Truscon, Rachel" uniqKey="Truscon R" first="Rachel" last="Truscon">Rachel Truscon</name><affiliation><wicri:noCountry code="no comma">Epidemiology and</wicri:noCountry></affiliation></author><author><name sortKey="Harrison, Sean" sort="Harrison, Sean" uniqKey="Harrison S" first="Sean" last="Harrison">Sean Harrison</name><affiliation><wicri:noCountry code="no comma">Epidemiology and</wicri:noCountry></affiliation></author><author><name sortKey="Mindell, David" sort="Mindell, David" uniqKey="Mindell D" first="David" last="Mindell">David Mindell</name><affiliation><wicri:noCountry code="no comma">Biology and</wicri:noCountry></affiliation></author><author><name sortKey="Simon, Carl" sort="Simon, Carl" uniqKey="Simon C" first="Carl" last="Simon">Carl Simon</name><affiliation><wicri:noCountry code="subField">Arbor</wicri:noCountry></affiliation></author><author><name sortKey="Monto, Arnold S" sort="Monto, Arnold S" uniqKey="Monto A" first="Arnold S." last="Monto">Arnold S. Monto</name><affiliation><wicri:noCountry code="no comma">Epidemiology and</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="2001-09-01">2001</date><biblScope unit="vol">184</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="542">542</biblScope><biblScope unit="page" to="546">546</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Ferrets were used as an animal model to study whether controlled transmission of type A influenza is similar to human transmission when sequence changes in HA1 are used as the outcome. Ferrets were infected initially with A/Sydney/5/97 (H3N2) or A/LA/1/87 (H3N2) intranasally, and transmission chains were established by housing infected ferrets with noninfected ferrets with no influenza antibody titer against the infecting virus. Ferrets infected with A/Sydney were seronegative for A/Sydney and A/LA; ferrets infected with A/LA were seronegative for A/LA but had hemagglutination inhibition titers against A/Sydney. Titers of naturally transmitted influenza were higher than those after direct intranasal infection, but lymphocyte counts from nasal washes diminished with transmission. Ferrets infected with A/LA had 2 amino acid differences in HA1 after transmission through 5 ferret cohorts, but those infected with A/Sydney had none. The results show the value of the ferret model. A/LA resembled the transmission of influenza in humans when under antibody pressure</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Michigan</li></region></list><tree><noCountry><name sortKey="Elias, Stephanie" sort="Elias, Stephanie" uniqKey="Elias S" first="Stephanie" last="Elias">Stephanie Elias</name><name sortKey="Harrison, Sean" sort="Harrison, Sean" uniqKey="Harrison S" first="Sean" last="Harrison">Sean Harrison</name><name sortKey="Mindell, David" sort="Mindell, David" uniqKey="Mindell D" first="David" last="Mindell">David Mindell</name><name sortKey="Monto, Arnold S" sort="Monto, Arnold S" uniqKey="Monto A" first="Arnold S." last="Monto">Arnold S. Monto</name><name sortKey="Simon, Carl" sort="Simon, Carl" uniqKey="Simon C" first="Carl" last="Simon">Carl Simon</name><name sortKey="Truscon, Rachel" sort="Truscon, Rachel" uniqKey="Truscon R" first="Rachel" last="Truscon">Rachel Truscon</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Herlocher, M Louise" sort="Herlocher, M Louise" uniqKey="Herlocher M" first="M. Louise" last="Herlocher">M. Louise Herlocher</name></noRegion><name sortKey="Herlocher, M Louise" sort="Herlocher, M Louise" uniqKey="Herlocher M" first="M. Louise" last="Herlocher">M. Louise Herlocher</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001839 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001839 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:B272032214F4DC7471507AF029E0C0D3C613D27F
|texte= Ferrets as a Transmission Model for Influenza: Sequence Changes in HA1 of Type A (H3N2) Virus
}}
| This area was generated with Dilib version V0.6.33. |  |